Usually, when a cut wound starts to heal, the forms a tissue matrix fully consisting of collagen. From this is when a scar is formed. But, it’s not the same case with individuals suffering from scleroderma- an auto-immune condition. Their tissue keeps growing even without a cut or injury.
This results in collagen overproduction plus fibroblasts. It mostly happens in body organs and the skin. The condition is typically accompanied by inflammation and pain. Most auto-immune conditions lack therapies for treating them, and scleroderma isn’t an exception. The limited treatment options for this condition make it fall under the ‘orphan disease’ category. However, there are thoughts that CBD can be an effective remedy to this condition. Well, let’s find out more from this article.
Scleroderma and the endocannabinoid system
Scleroderma is said to affect between 50 and 300 individuals in a million. It’s an uncommon illness with several types and has varied symptoms. For instance, in some people, it comes as a minor irritation and is life-threatening for others.
The condition results from excessive collagen production caused by an attacked connective tissue. The protein collagen is necessary for maintaining a healthy connective tissue. Nevertheless, its overproduction leads to a scarring named fibrosis. When the condition is mild, fibrosis causes a thickened and hard skin. In worse cases, it affects the blood vessels and internal organs. The main organs targeted are the lungs, esophagus, kidneys, and the heart.
At first, scleroderma demonstrates as an unusual skin problem. A skin illness happens because of endocannabinoid system dysfunction. That’s why you’ll see people suffering from scleroderma, acne, and psoriasis. This system is vital for promoting skin homeostasis that stimulates the production of a signaling mechanism for a healthy skin. The endocannabinoid system may relate very well with scleroderma medicines because of the overexpressed CBD receptors in scleroderma fibroblasts. Again, the enzyme that digests the endocannabinoid anandamide is limited in patients with this skin condition.
How good is CBD oil for scleroderma?
Is CBD oil good for scleroderma condition? Well, let’s first understand the working of CBD, then we’ll how it goes with the disease. The cannabis plant contains hundreds of components, and CBD is among them. Another familiar compound is THC that has intoxicating properties. Unlike THC, CBD lacks these characteristics, so anyone using products containing it shouldn’t expect to become ‘high’.That means there’s no mind and body effect after use. People have recently started using CBD as a remedy for relieving several ailment symptoms and maintaining proper wellbeing.
Just due to the recent popularity CBD is gaining, there are still limited findings of how useful it is. Nevertheless, some promising evidence has been shown about its effectiveness against inflammation. Isn’t this good news to the people suffering from the scleroderma disease? The CBD has been proved to alleviate pain caused by inflammation. That alone isn’t CBD’s benefit; we’ve got more. Being a cannabinoid, CBD can interact well with a region called the endocannabinoid system, common as the ECS. The system basically plays crucial body activities, including moo, immunity, sensation, and movement regulation.
Experts in this CBD’s power to treat now believe it can be beneficial in treating scleroderma symptoms. More clinical trials are in place to get the verdict on cannabinoid’s help for this condition. Focus on these trials mainly look at synthetic CBD, such as lenabasum, and the hopeful impact. From the studies, it’s as if the cannabinoid compound decreases pain and inflammation and suppresses fibrosis. Additionally, it suppresses tissue scaring. All these happen without overwhelming the body’s immune system. This is unlike what most convectional scleroderma treatments do.
Can CBD oil help in scleroderma?
If we want to understand CBD’s working mechanism on scleroderma, it’s relevant to look closely at the ECS. The endocannabinoid system dominates most tissues in the body. It composes multiple chemicals and cell receptors referred to as endocannabinoids. The body releases these compounds naturally. After that, CBD receptors bind to these compounds resulting in a stimulation of numerous benefits. Endocannabinoids also imitate the cannabinoid’s molecular shape, which is an advantage. This implies that CBD can powerfully impact on ECS for better results.
The cannabinoid is also thought to mingle with other receptors out of the ECS. Among these receptor types are the PPAR, short form for peroxisome proliferator-activated receptor. This receptor consists of three forms, namely gamma, alpha, and beta. It’s the major receptor as far as scleroderma is concerned. Studies demonstrated that it can not only bind to the synthetic cannabinoids but also the endocannabinoid system. Seemingly, this combination’s effort is the core reason why the compounds are useful in reducing collagen accumulation and fibrosis.
Despite the need for further research, it seems cannabinoid can do a similar job. Thisis evident from a study in 2016, which concluded that THC and CBD impact largely on PPAR gamma receptors, the same way other cannabinoids do. The data collected from the study added that it’s how CBD counters various anti-inflammatory and analgesic effects. Additionally, the cannabinoid oil used for easing scleroderma symptoms is safe, except for a few side effects accompanied by its effect.
The bottom line
Many people get desperate for lacking treatment choices, especially when the condition is painful and life-threatening. As a result, most of them go for various options as long they are relieved. No wonder numerous individuals are choosing CBD.
While studies on CBD are limited and still in progress, more clinical trials look deeply into synthetic CBD’s effects. But CBD oil is worth for use until these treatments become popular and largely available. Also, don’t forget that CBD oil isn’t another choice for proper medication. It’s best to check with your doctor before taking it in, more so for first-timers. Again, CBD may be considered safe for use, but it has some side effects. For instance, it may cause drug interference when having CBD alongside other medicines. That’s why a physician helps give guidance on the right dosage for your skin condition.