BUYINI UBUDLELWANO PHAKATHI KWE-CBD TOPICALS KANYE NE-BLOOD THINNERS

Nakuba uwoyela we-CBD uyisinqumo esihle kakhulu sokwehlisa ukuvuvukala nobuhlungu bamalunga, kunengozi yokusabela kabi lapho kuhlanganiswa nemithi enciphisa igazi.

Xhumana nodokotela wakho ukuze ubone ukuthi ukusebenzisa isihloko se-CBD kuzoba nemiphumela emibi yini. Udokotela angaphakamisa ukuhlolwa kwegazi kanye nokomzimba ukuze aqinisekise ukuthi ukusebenzisa izithasiselo ngeke kuphazamise umzimba wakho.

Blood Thinners kanye Grapefruits

Okunye ukudla (okufana ne-grapefruit, itiye eluhlaza, notshwala) kungaba nomthelela endleleni izidakamizwa ezisebenza ngayo. I-Grapefruit ingase ikhuthaze ukukhululwa okusheshayo noma okude kwezinto ezinciphisa igazi, okungase kubangele imithi engasebenzi noma ukweqisa okunobuthi. Ngokunciphisa ikhono lomzimba lokukhiqiza ama-enzyme, i-grapefruit ingamelana nezinto ezinciphisa igazi njenge-felodipine ne-nifedipine. Izinto ezinciphisa igazi zingase zingasebenzi njengoba bekuhleliwe njengoba ama-enzyme adingekayo ukuze amunce udoti futhi avimbele imiphumela yomuthi.

I-Cytochrome P450 (CYPs)

The ama-enzyme e-cytochrome P450 ziwumndeni we-monooxygenase wama-enzyme aqukethe i-hemp njenge-cofactor. Lawa maprotheni enza ama-steroids, ama-fatty acids, kanye ne-xenobiotics ezilwaneni ezincelisayo futhi abalulekile ekususweni kwamakhemikhali, ukuhlanganiswa kwamahomoni, kanye nokuwohloka. U-Estabrook, Cooper, noRosenthal bachaza indima ye-CYP njenge-catalyst ekuhlanganiseni ama-hormone e-steroid kanye ne-metabolism yezidakamizwa ku-1963. Lawa maprotheni ayadingeka ukuze enze amakhemikhali okuzivikela, ama-fatty acids, nama-hormone ezitshalweni. I-P4503A4 yi-cytochrome ehlobene nokusebenzisana kwemithi emzimbeni womuntu. Yiwona ophethe ukuthumela ama-impulses kagesi ebuchosheni, okubangela ukuthi ukukhiqizwa kwama-enzyme kuqale. I-Grapefruit ne-CBD iqondise le cytochrome, esiza ukunciphisa ukukhiqizwa kwe-enzyme futhi ivumela ubuchopho ukuthi bukhiqize amahomoni isikhathi eside.

Ama-catalyst asetshenziselwa ukuphazamisa imijikelezo evamile. Amaprotheni abalulekile, kodwa ukuwanciphisa kungaba yinzuzo kwezinye izimo. Izidakamizwa zibambezela ukwakheka kwamakhemikhali nezinye izinqubo ngokubambezela amaprotheni.

Amagilebhisi kanye ne-Cytochromes

I-Grapefruit, njenge-CBD, ivimbela i-CYP3A4 ukuvumela umzimba ukuthi ukhiqize ama-compounds amaningi. Njengoba i-grapefruit yehlisa i-cytochrome, umzimba awusakwazi ukusebenzisa umuthi wokunciphisa igazi ngendlela efanele njengangaphambili. Ingamuncwa ngokushesha kakhulu noma kancane kakhulu, ibe yingozi empilweni. Ake sithi igama lomuthi lihlanganisa "i-grapefruit," bona udokotela wakho oyinhloko ngaphambi kokuwusebenzisa Izihloko ze-CBD.

Ingabe Izihloko Ezifundwayo Ziphephile?

Uhlelo lwe-endocannabinoid lutholakala cishe kuzo zonke izitho zomzimba. Lapho ama-topical esetshenziswa esikhumbeni, uhlelo lwe-endocannabinoid luyaqalwa, lukhiqize amahomoni alwa nokuvuvukala, kube lula ukukhululeka kobuhlungu. Enye inzuzo yokusebenzisa Izihloko ze-CBD ekwelapheni izinhlungu ukuthi angeke ithwale izingozi zempilo njengeminye imithi efana ne-Fentanyl noma i-OxyContin, edala ukulutheka kanye nokuba buthakathaka kwesistimu yokuphefumula.

Ingabe Kufanele Usebenzise Izihloko Ze-CBD

I-Cannabidiol, njengesengezo sezempilo, ayinalo ucwaningo oludingekayo kanye nezixazululo ezisebenzayo zokwenza noma yikuphi ukugomela okubanzi kokuthi isebenza kanjani. Kukhona izinkundla eziku-inthanethi ezinikelwe kubantu abahlukunyezwa yizinhlungu zamalunga, futhi abaningi babo babelana ngezindaba zabo zokusebenzisa i-CBD ngokuhlangana nabantu abanciphisa igazi.

Ayikho enye indlela yemikhiqizo ye-CBD yekhwalithi ephezulu. Bathambekele ekwenzeni ngendlela okufanele benze ngayo. Izihloko ze-CBD ziyindlela enhle kakhulu yokukhulula ubuhlungu obuhlangene nokuvuvukala. Nokho, kufanele uthole izimpahla ezizokwenza kahle.

Ungayithola Kanjani Imikhiqizo Engcono Kakhulu ye-CBD

Funda futhi Uqonde Amalebula

Kubalulekile ukufunda amalebula ukuze uhlole ukuthi noma yiziphi izithako ezishiwo zingase zihlanganyele kabi neminye imithi. Hlola isithako esisebenzayo kanye nephesenti.

Bheka Imibiko Yelebhu

Lawa mafayela afaka phakathi ulwazi mayelana nokuqukethwe kwesengezo sakho. Izibulala-zinambuzane, umanyolo, ukungcola, izinsimbi ezisindayo, nokuqukethwe kwe-cannabidiol konke kubikwa kulezi zifundo. Uma inkampani ingavezi noma yimiphi imiphumela yelebhu, kungcono ukuthi uqhubekele esinyathelweni esilandelayo ngoba lokhu kungaba yinkinga.

Izibuyekezo Customer

Izibuyekezo futhi zinikeza ingcebo yolwazi oluwusizo. Uma abathengi bomthengisi banelisekile, ngokuvamile kusho ukuthi imikhiqizo ingeyekhwalithi ephezulu kanye nesevisi eyanele.

Isitoko Somthengisi

Amafomula ochwepheshe ahlinzeka ngezidingo ezahlukahlukene avame ukutholakala ku-assortment enkulu.

Isiphetho

Iseluleko esihle kakhulu ukukhuluma nodokotela wakho mayelana nemiyalelo yakho yamanje nokuthi i-CBD izobahlanganisa nani. Odokotela bavame ukuhlela ukuhlolwa kwegazi nokuhlolwa ngokomzimba ukuze babone ukuthi umzimba wakho usabela kanjani ekuhlanganisweni kwe-cannabidiol negazi elincanyana. Ezimweni eziningi, ukuhlanganisa incwadi kadokotela enciphisa igazi nomthelela omncane akubangeli ingozi empilweni.

Okubhekwayo

I-Fujii-Kuriyama Y, Mizukami Y, Kawajiri K, Sogawa K, Muramatsu M. Isakhiwo esiyinhloko se-cytochrome P-450: ukulandelana kwekhodi ye-nucleotide ye-phenobarbital-inducible cytochrome P-450 cDNA kusuka esibindini segundane. I-Proc Natl Acad Sci US A. 1982;79(1982):2793–2797. [Isihloko samahhala se-PMC] [I-PubMed] [-Google Scholar]