INGABE UFUTHA WE-CBD UKWENZA UBUTHONGO?

INGABE UFUTHA WE-CBD UKWENZA UBUTHONGO?

Lapho kuphasiswa uMthethosivivinywa Wepulazi ngo-2018, i-hemp yezimboni yasemthethweni, kanjalo nowoyela we-CBD owawune-THC engaphansi kuka-0.3%. I-cannabinoid ibonakala iwusizo kunoma yini, nakuba kungenabufakazi obanele besayensi bokufakazela ukuthi ezinye izimangalo ziyiqiniso. Lesi sihloko sibheka ukuxhumana phakathi kwamafutha e-CBD nokulala.

Ukuqonda Amafutha e-CBD

uwoyela CBD iyikhemikhali futhi ingenye yezinhlanganisela ezisebenzayo ezingaphezu kwekhulu ezibizwa ngokuthi ama-cannabinoids, ngokwemvelo atholakala ezitshalweni ze-cannabis. Ingatholakala ezitshalweni ze-hemp noma insangu, kodwa izinhlobo eziningi zemikhiqizo zigxila kuwoyela we-CBD osuselwe ku-hemp okugxilwa kwawo okuphelele kwe-THC kungadluli u-0.3%. Ayinayo imiphumela 'ephezulu' noma ye-psychoactive exhunywe ku-THC. Amafutha e-CBD atholakala kalula njengama-edibles, ama-tinctures, ama-vapes, ama-capsules, nama-topical afaka noma yikuphi ukwakheka kokuthathu okulandelayo;

Amafutha e-CBD agcwele i-spectrum

Lawa mafutha ane-terpenes, i-flavonoids, i-CBD, i-psychoactive THC, namanye ama-cannabinoids amaningi, afaka i-CBC, i-CBN, i-CBT, i-CBG, ne-CBDa. Kuxhunyaniswe nomphumela ogcwele we-entourage. 

I-Broad-spectrum CBD Amafutha

Iqukethe ama-terpenes, ama-flavonoid, nama-cannabinoids amaningi njengakuwoyela we-CBD we-spectrum egcwele futhi ixhunywe nomthelela ophelele wokugqugquzela. Ayinayo i-psychoactive THC.

Isolate-based CBD Amafutha

 Ama-Isolates ane-CBD njengengxenye yodwa, engenawo amanye ama-cannabinoids, ama-terpenes, noma ama-flavonoids.

Ingabe Amafutha e-CBD Angasiza Ngokulala?

Abasekeli bakawoyela we-CBD bathi kungenza ukwelashwa okuhle kokulala okuthuthukisa izinga lokulala futhi kwelaphe ukuqwasha, kodwa abukho ubufakazi obanele besayensi bokufakazela lokhu. Ngezansi okushiwo ucwaningo lwangaphambili mayelana namafutha e-CBD okulala;

  • Isibuyekezo sika Vučković et al. (2018) ibonisa ukuthi uwoyela we-CBD ungasiza ngokulala ngokunciphisa ubuhlungu obungapheli.
  • Ocwaningweni olwenziwe ngu Shannon et al. (2019) okubandakanya izifundo ezingama-72, i-66.9% yabahlanganyeli ibike ukuthi bathole ukulala okungcono ngemuva kokuthatha amaphilisi e-CBD angama-25 mg. Kodwa-ke, inani labantu bocwaningo belincane kakhulu ukuthi lingakha ukubaluleka kwezibalo. Ucwaningo lubike ukuthi u-79.2% wabahlanganyeli waba nokukhathazeka okuncishisiwe, okwakungathuthukisa ukulala komuntu.
  • Ucwaningo olwenziwe ngu Chagas, et al. (2014) waphawula ukuthi uwoyela we-CBD ungasiza nge-RBD, ekugcineni athuthukise ukulala, kodwa usayizi wesifundo socwaningo wawumncane kakhulu ngokubaluleka kwezibalo.

Nokho, izifundo zinemikhawulo. Iningi lazo linezibalo zabantu ezincane ezibalulekile emhlabeni wangempela kodwa azisho lutho ngokwezibalo. Ngaphandle kwalokho, iningi labo liyavuma ukuthi kunesidingo sokuqhubeka nezifundo ngaphambi kokusekela lokho abakutholile, ikakhulukazi ngoba abakwazanga ukuchaza abakuqaphelile.

Ingabe Amafutha e-CBD Angakwenza Ulale Phakathi Nosuku?

Isigaba sihlola uwoyela we-CBD njenge-ejenti ekhuthaza ukulala kwasemini. Alukho ucwaningo olwanele lokusekela lokhu. Uma kukhona, uwoyela we-CBD unezinto ezidambisa ingcindezi kanye nokukhathazeka ezibonakala zikhuthaza ukuzola nokugxila kubantu phakathi nosuku. Nakhu okushiwo ucwaningo mayelana nowoyela we-CBD nokukhathazeka;

  • Ocwaningweni olwenziwe ngu Bergamaschi, et al. (2011), abaqhudelana bezinkulumo zomphakathi bathathe uwoyela we-CBD ngaphambi kokuzivocavoca futhi babika ukukhathazeka okuncane.
  • Olunye ucwaningo olwenziwe ngu Crippa, et al. (2011) waphawula ukuthi uwoyela we-CBD ungasiza ekwelashweni kokukhathazeka komphakathi.
  • Ngokuvumelana ne Hundal, et al. (2018), uwoyela we-CBD awuzange ubonise izimpawu zokuthuthukisa ukukhathazeka ne-paranoia kodwa kubonakala sengathi ukwandisa ukukhathazeka kubantu.

Lezi zifundo zivuma ezinkulu kunazo zonke, nakuba eyodwa erekhodiwe imiphumela engemihle. Noma kunjalo, iningi labo lasebenzisa isibalo esincane sabantu, okuthi, nakuba singokoqobo, singameli inani labantu abaningi. Ngaphandle kwalokho, abazange babheke imiphumela yesikhathi eside kawoyela we-CBD, futhi asikho isiqiniseko sokuthi imiphumela efanayo izobonwa uma ukusetshenziswa kukawoyela we-CBD kuqhubeka isikhathi eside.

I-CBD Amafutha Ngokuphikisana ne-THC Yokulala

I-THC namafutha e-CBD yimikhiqizo edumile yensangu, futhi abanye abantu babheka ku-THC ukuthola izinzuzo zokulala. Noma kunjalo, uwoyela we-CBD uthembisa izakhiwo ezingcono zokulala kune-THC. Ngaphandle kwalokho, i-THC iyasebenza ngokwengqondo, futhi uma isiza ngokulala nganoma iyiphi indlela, kusengenzeka ikwenze 'uphakame.' Kanjalo, abantu abaningi bayayigwema futhi bakhethe uwoyela we-CBD, okuthi naphezu kokungenabo ubufakazi obanele bokusekela izinzuzo zokuthuthukisa ukulala, ngeke kukwenze 'uphakame' noma 'ukhandwe ngamatshe.'

Ingabe Amafutha e-CBD Aphephile Ekulaleni?

Ngenkathi ucwaningo ngo I-Iffland & Grotenhermen (2017) ikhombisa ukuthi uwoyela we-CBD uphephile ukulala, isimo somhlaba wangempela singahluka. Abasebenzisi be-CBD balindele ukuzwa uhla lwemiphumela engemihle, kodwa eminye iyethusa. Ngokusho kwe-FDA, eminye imiphumela emibi engaba khona yokuphuma kwe-cannabis, uwoyela we-CBD wawuhlanganisa ukulahlekelwa isifiso sokudla, izinkinga zesisu, ukushintsha kwemizwa, nokulimala kwesibindi.

Isiphetho

Ezinye izifundo ziphakamisa ukuthi uwoyela we-CBD ungakhulisa ukulala komuntu futhi uthuthukise izinga lokulala, kodwa abukho ubufakazi obanele bokufakazela lokhu. Uwoyela we-CBD ubonakala sengathi mancane amathuba okuthi enze umuntu alale phakathi nosuku. Noma kunjalo, kunesidingo sezifundo ezengeziwe zokuhlola izinzuzo zayo ezidambisa ukukhathazeka ezihlobene nokuphaphama phakathi nosuku. Sekushiwo lokho, uwoyela we-CBD kungenzeka ungaphephile wonke njengoba sekushiwo, futhi ungaholela emiphumeleni engathandeki ethambile, ehlanganisa ukulahlekelwa ukudla, ukulimala kwesibindi, ukushintsha kwemizwa, kanye nezinkinga zesisu.

Okubhekwayo

I-Bergamaschi, MM, Queiroz, RHC, Chagas, MHN, De Oliveira, DCG, De Martinis, BS, Kapczinski, F., … & Crippa, JAS (2011). I-Cannabidiol Yehlisa Ukukhathazeka Okubangelwa Ukukhuluma Komphakathi Okulingiswayo Ekwelapheni-Iziguli Ezingenalwazi Zoku-Social Phobia. I-Neuropsychopharmacology, 36(6), i-1219-1226.

Chagas, MH, Eckeli, AL,

I-Zuardi, AW, Pena-Pereira, MA, Sobreira‐Neto, MA, Sobreira, ET, … & Crippa, JAS (2014). I-Cannabidiol

Ingathuthukisa Izindlela Zokuziphatha Ezihlobene Nokulala Eziyinkimbinkimbi

Okuhlotshaniswa Ne-Rapid Eye Movement Sleep Behavior Disorder ku-Parkinson's Disease

Iziguli: Uchungechunge Lwecala. Ijenali Yekhemisi Yezokwelapha Nezokwelapha, 39(5),

564-566.

ICrippa, JAS, Derenusson,

GN, Ferrari, TB, Wichert-Ana, L., Duran, FL, Martin-Santos, R., …

& Hallak, JEC (2011). Isisekelo Se-Neural Of Anxiolytic Effects Of

I-Cannabidiol (CBD) Ku-Generalized Social Anxiety Disorder: Umbiko Wokuqala.

Ijenali ye-Psychopharmacology, 25(1), i-121-130.

Hundal, H., Lister, R., Evans,

N., Antley, A., Englund, A., Murray, RM, … & Morrison, PD (2018). I

Imiphumela Ye-Cannabidiol Emcabangweni Wokushushiswa Nokukhathazeka Ngendlela Ephakeme

Iqembu leParanoid. Ijenali ye-Psychopharmacology, 32(3), i-276-282.

I-Iffland, K., & Grotenhermen,

F. (2017). Ukubuyekezwa Kwezokuphepha Nemiphumela Emibi Ye-Cannabidiol: Ukubuyekezwa Kwe

Idatha Yomtholampilo Kanye Nezifundo Zezilwane Ezifanele. Ucwaningo lweCannabis kanye neCannabinoid,

2(1), i-139-154.

Shannon, S., Lewis, N., Lee,

H., & Hughes, S. (2019). I-Cannabidiol Ekukhathazekeni Nokulala: Icala Elikhulu

Uchungechunge. I-Permanente Journal,

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Vučković, S., Srebro, D., Vujović,

KS, Vučetić, Č., & Prostran, M. (2018). Ama-Cannabinoids Nobuhlungu: Imibono Emisha Evela Kuma-Old Molecules. I-Frontiers In Pharmacology, 1259.

MS, University of Tartu
Ungoti wokulala

Ngisebenzisa ulwazi oluzuziwe lwezemfundo nobuchwepheshe, ngeluleka iziguli ezinezikhalo ezihlukahlukene mayelana nempilo yengqondo - isimo sengqondo esicindezelekile, uvalo, ukungabi namandla nesithakazelo, ukuphazamiseka kokulala, ukuhlaselwa ukwesaba, imicabango ecindezelayo nokukhathazeka, ubunzima bokugxila, nokucindezeleka. Ngesikhathi sami sokuphumula, ngithanda ukupenda futhi ngihambe ngezinyawo ezinde ogwini lolwandle. Enye yezinto ezingikhathazayo zakamuva yi-sudoku - umsebenzi omuhle kakhulu wokuthulisa umqondo ongakhululekile.

Okwakamuva okuvela ku-CBD