INGABE UFUTHA WE-CBD UNGAZIKHULULA IZIMPAWU ZE-DOWN SYNDROME?

Wake waba ne-down syndrome? Ucabanga ukuthi uwoyela we-CBD ungadambisa izimpawu ze-down syndrome? Nakhu konke okudingeka ukwazi mayelana nowoyela we-CBD kanye nomthelela wawo ku-down syndrome.

I-CBD ingenye yama-cannabinoids amaningi anezinzuzo eziningi zezokwelapha eziqinisekisa ukuthi unempilo enhle. Nokho, imiphumela yayo ezimeni ezahlukene kanye nezimpawu kusanqunyelwe. I-Down syndrome yisimo esivamile sofuzo esenzeka lapho umuntu ene-chromosome eyengeziwe. I-chromosome eyengeziwe ithinta ukukhula komntwana okuvamile, okuholela ekukhulisweni kancane kobuchopho nomzimba. Ngokuvamile, izinselele ezingokomzimba nezingokwengqondo zingaholela kalula ekukhubazekeni kwentuthuko. Ngaphezu kwalokho, ingane eshiya i-down syndrome isengozini kakhulu ezifweni, inenkinga yokufunda kancane, nokunye. Lokhu kwenza abantu bazibuze ukuthi uwoyela CBD kungaba impumuzo engcono kakhulu yesimo esinjalo. Ngokuphambene, ezinye izifundo ziphakamise ukuthi i-CBD ingasiza nge-down syndrome. Kusenobufakazi obuncane obusekela lezi zimangalo. Lesi sihloko sizokwabelana ngezifundo eziningi ngemiphumela yamafutha e-CBD ku-down syndrome.

UKUQONDA KAFUTHA WE-CBD

I-Cannabidiol (CBD) iyinhlanganisela yamakhemikhali esebenzayo etholakala esitshalweni se-cannabis sativa noma insangu (hemp). Le cannabinoid ingenye esebenza kakhulu uma iqhathaniswa nezinye izinhlanganisela ezitholakala ku-hemp. Ngaphezu kwalokho, i-cannabidiol (i-CBD) itholakala ngezindlela ezahlukene, kufaka phakathi amaphilisi, izinto ezidliwayo, izihloko, ama-vapes, ama-tinctures, nokuningi. Lokhu kukuvumela ukuthi ukhethe umkhiqizo we-CBD ofanele okuncamelayo nokunambitha. Lawa mafomu e-CBD futhi eza ngokuthanda okuhlukile nezakhiwo ukuze ukhonjwe kalula. Ngokungafani ne-tetrahydrocannabinol (THC), i-CBD ayidaki futhi ayinangqondo, okusho ukuthi ngeke ikuthole uphakeme noma kubangele imiphumela emibi kakhulu. Ngokuvumelana ne Leszko et al. (2021), Uwoyela we-CBD waziwa ngezinzuzo zawo zezempilo ezinkulu. Imikhiqizo ye-CBD izosiza ekunciphiseni ingcindezi, ukukhathazeka nokudangala, ithuthukise iphethini yakho yokulala, inikeze ukukhululeka kobuhlungu, nokunye. Ngokuvamile, iwumkhiqizo ofanele wezimo ezahlukene, kuhlanganise ne-down syndrome.

UHLANGANISA KANJANI UFUTHA WE-CBD NOHLELO LABANTU?

Ngokuvumelana ne Romano et al. (2013), Uwoyela we-CBD kanye nezinzuzo zawo ngomzimba womuntu awaziqondi kahle. Lokhu kufaka phakathi ukuthi isebenza kanjani noma iluthinta kanjani uhlelo lwakho. Ngokuvamile, umzimba wakho wakhiwe ama-receptors, ama-enzyme, nama-endocannabinoids ohlelweni lwe-endocannabinoid. Lolu hlelo lusebenzisana ne-cannabidiol (CBD) namanye ama-cannabinoids. Ngaphezu kwalokho, uhlelo lwe-endocannabinoid lwaziwa nangokuthinta imisebenzi ebalulekile yomzimba kanye nezinqubo ezifana nokulala, ukukhathazeka, ingcindezi, imizwa, ukungavikeleki komzimba, i-metabolism, ukusutha, ukuvuvukala, ubuhlungu, nokuningi. Ngakho-ke, ngenxa yokuxhumana okuqondile phakathi kwe-cannabidiol nohlelo lwe-endocannabinoid, uwoyela we-CBD kukholakala ukuthi unamandla okusiza kunoma yisiphi isimo, okuhlanganisa nezimpawu ze-down syndrome. Nokho, kunocwaningo lwesayensi olulinganiselwe olufakazela lezi zimangalo. Ngokuvamile, yingakho i-Food and Drug Administration (FDA) ingakagunyazi noma yiziphi zalezi zimangalo.

INGABE UFUTHA WE-CBD UNGASIZA NGEZIMPAWU ZOKUPHATHWA KWE-DOWN SYNDROME?

Ngokuvumelana ne U-Marín et al. (2011), Uwoyela we-CBD ungasiza ekudambiseni izimpawu ze-down syndrome. Kodwa-ke, kusenesidingo socwaningo olwengeziwe kanye nezifundo zokuthi uwoyela we-CBD ungasiza kanjani nge-down syndrome. Olunye ucwaningo luphakamisa ukuthi uwoyela we-CBD ungumkhiqizo ongcono kakhulu we-down syndrome, kodwa kunocwaningo olulinganiselwe lokuthi ungasetshenziswa yini njengokwelashwa okuyinhloko kwalesi simo. Ngaphezu kwalokho, uwoyela we-CBD waziwa ngezinzuzo zawo zezokwelapha, okubandakanya ukukhululeka kobuhlungu nokuvuvukala, ukuncipha kwengcindezi, nokunye okuningi. Lokhu kuwubufakazi bokuthi ingenye yama-cannabinoids angcono kakhulu angasiza ekuqedeni izimo nezimpawu ezahlukahlukene. Kodwa-ke, lapho usebenzisa uwoyela we-CBD enganeni, kubalulekile ukufuna usizo kudokotela ukuze uvimbele noma yimiphi imiphumela emibi kakhulu. Ngaphezu kwalokho, qiniseka ukuthi usebenzisa umthamo onconyiwe we-CBD ukuze uphumelele futhi uvikeleke. Amafomu e-CBD ahlukene ayatholakala emakethe, futhi ukukhetha elungele ingane yakho kungase kube inselele. Okokugcina, qiniseka ukuthi wenza ucwaningo olwengeziwe mayelana nokuthi uwoyela we-CBD uphephile yini enganeni yakho noma cha ngaphambi kokuwusebenzisa.

IMUPHI UFUTHA WE-CBD OKUMELE UWUWUTHATHE NGEZIMPAWU ZAMA-SYNDROME?

Ngokuvamile, uwoyela we-CBD neminye imikhiqizo ehlobene ye-cannabidiol inocwaningo olulinganiselwe ngemiphumela yayo ezimpawu ze-down syndrome. Kodwa-ke, uma kufanele usebenzise uwoyela we-CBD ukuze unciphise izimpawu ze-down syndrome, cabanga ngokubonana nodokotela wakho kusengaphambili. Lokhu kuzokusiza ukuthi uqonde umthamo kanye namafutha e-CBD okufanele uwadle njengoba usaqala. Ngaphezu kwalokho, izinhlobo eziningi zikawoyela we-CBD azilona iqiniso, futhi imininingwane eminingi engaqondile ingakudukisa. Ngenxa yalokho, umuntu kungenzeka athathe umthamo kawoyela we-CBD ngaphezulu noma ngaphansi kunalokho obekuhlosiwe. Futhi, ungasebenzisa kalula i-THC ngaphandle kwemvume yakho.

IZINSELELE EZIKHONA ZAMAFUTHA E-CBD EZIMPAWU ZAMA-DOWN SYNDROME

Ngenkathi izifundo ezahlukahlukene ziyethembisa futhi ziphakamisa ukusebenzisa uwoyela we-CBD ku-down syndrome, izinselelo ezimbalwa ezikhona zikhona. Zihlanganisa;

Ucwaningo luphakamisa kuphela ukuthi uwoyela we-CBD ungadambisa lezo zimpawu ze-down syndrome, kodwa abukho ubufakazi besayensi bobudlelwano phakathi kwesistimu ye-endocannabinoid nesimo.
Izinga uhlelo lwe-endocannabinoid oluthinta ngayo noma yisiphi isimo sofuzo akucaci.
Ucwaningo oluningi olukhona lubandakanya izilwane, okuzenza zingasebenzi kahle. Izifundo ezinomkhawulo kubantu zenza imikhiqizo ye-CBD iphephe futhi isebenze kahle.
Noma ngabe yiziphi izimangalo kuwoyela we-CBD nokuthi yini engasiza ukuxazulula ohlelweni lwakho, kusenocwaningo olulinganiselwe olusekela lezi zimangalo.
Imikhiqizo eminingi ye-CBD ayivunyelwe yiFood and Drugs Administration (FDA), okuyenza ingaphepheki kangako.
Imikhiqizo eminingi ye-CBD ayinawo umthamo wangempela, okwenza kube nzima ukwazi umthamo onconywayo.
Eminye yemikhiqizo ye-CBD ayihlanzekile (inengaphezulu kuka-0.3% iTHC), okwenza kube inselele ukuqonda ukuthi iyisengezo esifanele yini sezimpawu ze-down syndrome.

UMUGQA WOKUPHAKATHI

Uwoyela we-CBD ungomunye wemikhiqizo esebenzayo ku-cannabis. Kuyaziwa futhi ngezinzuzo zayo eziningi zezempilo ekuthuthukiseni impilo yakho yonke. I-Down syndrome yisimo esivamile esithinta izingane. Ishintsha inqubo yabo evamile yokukhula, ngaleyo ndlela iholele kokubili izinselele ezingokomzimba nezingokwengqondo. Ngaphandle kocwaningo olulinganiselwe kanye nezifundo ngemiphumela kawoyela we-CBD ku-down syndrome, usengasetshenziswa, kodwa ngaphansi komyalelo oqinile. Ngokuvamile, ngaphambi kokunikeza ingane yakho uwoyela we-CBD, cabanga ngokuvakashela udokotela wakho ukuze uthole imiyalelo. Udokotela wakho uzokuqondisa efomini elilungile le-CBD, ukuthi ulisebenzisa kanjani, kanye nomthamo ongawusebenzisa. Lokhu kuzovimbela ingane yakho kunoma yimiphi imiphumela emibi kakhulu.

IZINDAWO ZOLWAZI

Shyama, M., Al-Mutawa, SA, Morris, RE, & Sugathan, T. (2018). Isipiliyoni se-Dental caries sezingane ezikhubazekile kanye nabantu abadala abancane. Impilo Yamazinyo Omphakathi, 18(3), 181-6.
I-Leszko, M., & Meenrajan, S. (2021). Izimo zengqondo, izinkolelo, kanye nokushintsha kwezimo zokusebenzisa uwoyela we-cannabidiol (CBD) phakathi kwabanakekeli babantu abanesifo i-Alzheimer's. Ukwelashwa Okuhambisanayo Kwezokwelapha, 57, 102660.
U-Marín, AS, & Graupera, JMX (2011). Isimo somsoco sabantu abakhubazeke ngokomqondo abane-Down syndrome. I-Nutriction hospitalaria, 26(5), 1059-1066.
I-Romano, LL, & Hazekamp, A. (2013). Amafutha ensangu: ukuhlolwa kwamakhemikhali komuthi ozayo osekwe yi-cannabis. Ama-Cannabinoids, 1(1), 1-11.